- While Nick is in the hospital, an older patient in the room with him dies of an unknown aliment and is rushed off by the doctors after they can't revive him. (Pilot)
- Peter Dawson apparently has and dies of the flu before reanimating. (So Close, Yet So Far)
- Griselda Salazar develops an infection from her crushed foot which eventually turns into septic shock. Griselda ultimately dies from her infection despite the best efforts of Doctor Bethany Exner. (Cobalt)
- Melissa Geary suffers from multiple sclerosis and she refuses to join the crew of The Abigail as a result. (We All Fall Down)
- After getting shot by Andrew Adams, (The Good Man) Ofelia Salazar develops an infection in her gunshot wound after running out of antibiotics. Her father refuses to ask for more antibiotics from the others and instead searches for some in the wreckage of Flight 462. Noticing this and deducing Daniel's intentions, Nick reveals that Daniel needs something a lot stronger than what he's got. Nick manages to find some which he discreetly gives to Daniel. (Ouroboros) By the time that the group arrives at the Abigail Vineyard, Ofelia's infection has cleared up from the antibiotics. (Sicut Cervus)
- The residents of La Colonia begin getting sick with an unknown illness with one dying of it, reanimating and attacking several people, including Alejandro Nuñez before he is put down by Nick. (Wrath)
- After surviving the destruction of the Abigail Vineyard, Daniel gets an infection in his burned leg which appears to have become gangrenous. However, he is found by Efrain Morales who gets Lola Guerrero to treat his injury and infection. (100)
- On the orders of Qaletaqa Walker, Ofelia infects the Broke Jaw Ranch militia with anthrax in their coffee in order to weaken the men for the impending invasion by the Hopi Tribe. Several militiamen die, but others recover, including Nick. (The Unveiling-Children of Wrath)
- Proctor John develops a growth pressing on his spine that paralyzes him from the waist down the pain from which Eddie treats with Oxycotin. With the reluctant help of Alicia Clark, Eddie is eventually able to remove the growth from Proctor John's back and restore his mobility. (Things Bad Begun)
- After John Dorie gets covered in walker blood, June warns him that she has seen people get sick from it as she helps John to clean up. (Laura)
- June reveals that while living at the FEMA Shelter, her daughter Rose got sick with pneumonia. June hid the illness and departed to successfully find antibiotics. However, during the three days that June was gone, Rose died of her illness, turned and caused the entire community to fall as a result. (Just in Case)
- John expresses concern that his still-healing gunshot wound is going to get infected from him being in the muck. (I Lose People...)
- Martha develops an infection in her gunshot wound from Wendell. Believing that accepting help makes people weak, Martha refuses the efforts of Morgan's Group to treat her and eventually allows herself to be bitten by a walker in order to ensure that she can't be saved. (MM 54-... I Lose Myself)
- Grace reveals that the survivors that were living at Lonestar Power & Light died of radiation poisoning when the reactor melted down, creating a number of radioactive walkers roaming the area. (The Hurt That Will Happen)
- After getting radiation poisoning, the residents of Camp Cackleberry paint their cabin walls with a message warning of the sickness that's inside. (The Hurt That Will Happen)
- Grace reveals to Morgan and Alicia that, despite being careful, she was "exposed to more alpha emitters than most people see in a lifetime" when Grace searched the plant for days for survivors after the meltdown. As a result, she will inevitably get sick and die from the radiation too, although Grace doesn't know how long she has left. (The Hurt That Will Happen)
- Tess' son suffers from asthma, causing her husband to leave the house in search of more medicine. After Ben dies and turns due to unknown causes, Morgan's group recovers the inhaler and brings it to the young boy. (Channel 4)
- While at Bridgeview Mall, Grace seeks to use the equipment in the Urgent Care clinic to see if she's getting sick from her radiation exposure after the Meltdown at Lonestar Power & Light. Grace explains to Morgan that "I've seen people die from radiation poisoning. I've seen people get cancer from it. Every time I cough, every time I lose my breath... every time I feel a butterfly in my stomach I... I wonder. I wonder if this is it, if this is the beginning of the end for me." When Morgan asks if there's something that she can do about it, Grace clarifies that "it'll be cancer. Thyroid, maybe in the lymph nodes. Before I might've had a fighting chance but... now? No way." However, in the end, Grace decides against getting the scan and finding out for sure. (210 Words Per Minute)
- Grace gets sick from what is presumed to be her radiation exposure, although June's efforts to determine it for sure with an ultrasound fail. (Today and Tomorrow, Channel 5) After examining Grace, Dr. Holt discovers that she's actually just pregnant and malnourished. (End of the Line)
- After getting shot in the shoulder by Virginia, (Humbug's Gulch) and then being rescued, stitched up and left with antibiotics by Dakota, (The Door) Morgan Jones develops an infection in his wound which the bullet was never removed from. Over the course of at least six weeks, the infection turns into gangrene. After Morgan kills Emile LaRoux, Isaac, a former Corpsman for the U.S. Marines, is able to remove the bullet and the gangrenous skin before he dies of a walker bite, allowing Morgan to recover from his infection and his wound. (The End Is the Beginning)
- The Doomsday Cult infects the Creative Visionaries Agency building with the bubonic plague using infected rats that they release inside. Dwight also falls ill with the plague during this time, possibly from getting bitten by a rat in his sleeping bag a few days before. With the help of Isabelle, Al locates antibiotics in the CRM's supplies on the roof to save the remaining residents. (Alaska) After meeting the cult and finding some of the CRM's maps in their possession, Al becomes convinced that the attack was actually aimed at the CRM drop site on the roof in the hopes of infecting one of the group's helicopters with the plague and spreading it to the CRM that way. (The Holding)
- Malcolm develops appendicitis and contacts June and Sarah for help. By the time that they finally arrive two days later, Malcolm's appendix has ruptured, and June is forced to perform an emergency appendectomy. However, Malcolm goes into shock from the infection, dies, turns and has to be put down by Sarah. (Bury Her Next to Jasper's Leg)
- Alicia Clark is bitten by a zombified Elias Vazquez and becomes sick despite amputating her arm. Will suggests that it is merely something like sepsis or tetanus from amputating her own arm in a drain, but Alicia begins to get reoccurring fevers, although she doesn't die and turn despite months passing by with antibiotics not causing her illness to go away. (PADRE) Paul notes that Alicia's fever wouldn't go down no matter what he put into her after finding Alicia unconscious. (Follow Me) Some time later, after reuniting with Morgan, Alicia tells him that she still gets fevers at night and that her condition hasn't improved at all. (The Raft) By the time of the Battle for Strand's Tower, Alicia is so weak that she occasionally collapses with Strand at one point giving her epinephrine to help keep her going. She later passes out completely. (Divine Providence) Alicia subsequently experiences greater hallucinations and weakness, but succeeds in rescuing Strand from the burning tower. Convinced that she will die soon, Alicia remains behind as the rest of Morgan's group leaves Texas for good on rafts. However, after collapsing for a final time, Alicia unexpectedly regains consciousness with her fever broken and her illness beaten, whether it was the walker bite infection or something else, making her the first person to survive the walker bite infection if that was what she had. (Amina) Seven years later, June reveals that Alicia did actually have the walker bite infection. June eventually realized that Alicia's previous exposure to high levels of radiation was what had allowed her own immune system to eventually fight it off, the radiation apparently weakening the infection enough for Alicia's body to beat it on its own. As a result, June attempts to develop a cure using radiotherapy which, while successful in stopping the infection in June's patients, is also fatal at the required levels. (Blue Jay) After the cure works on Finch, June tells Madison that Shrike thinks that there might be a genetic factor in Alicia and Finch's survival too, one that Madison could share. While June admits that anything's possible, she doesn't know for sure. (Odessa) After meeting Ada, Strand asks about Alicia's illness. The woman tells Strand that Alicia's fever had stopped, but she really doesn't know beyond that as Alicia didn't spend much time with her. (Keeping Her Alive) When Alicia reunites with her mother over seven years after beating the infection, she is fully healthy again with no signs of lingering sickness. (The Road Ahead)
- After going to get an elevator part in a building that is radioactive and filled with radioactive walkers, Garcia gets exposed to deadly radiation and becomes terminally ill. As a result, he throws himself from Strand's Tower in order to continue protecting it as a part of the walker moat. (Mourning Cloak)
- After going to get an elevator part, Charlie collapses and, like Garcia, gets diagnosed with terminal radiation sickness. Although Charlie took precautions, Grace tells Ali that sometimes that's not enough. According to June, Charlie should make the most of the time that she has left now. (Mourning Cloak) Charlie is later bedridden with radiation burns and June states that there's nothing that can be done for her with the amount of exposure that she's had aside from keeping Charlie comfortable for her remaining time. (Sonny Boy) Seven years later, Daniel presumes that Charlie had ultimately died of her illness, but he can't be sure as PADRE separated them, keeping Daniel from being able to keep his promise that he would be at Charlie's side when she died. (Odessa) It's later revealed that Charlie is still alive, and she explains that, unlike June at the Tower, PADRE had what they needed to cure Charlie's illness, although they weren't sure that the treatment would work and they gave Charlie to Luciana just in case she died and turned. (Iron Tiger)
- John Dorie Sr. reveals to June that he also has terminal radiation sickness, having gotten it when he went to rescue Charlie, getting exposed to the same deadly radiation that she did despite being quick and careful. (Sonny Boy)
- Upon being taken to PADRE, Mo is given shots to keep her from getting sick and to keep her from getting other kids sick. (Remember What They Took From You)
- Finch gets appendicitis, forcing Dwight and Sherry to get him medical attention. After June ambushes them, she reluctantly agrees to perform the appendectomy at her abandoned lab. June later successfully removes Finch's appendix before it bursts and reassures his parents that Finch is stable before Shrike arrives. (Blue Jay) Shrike later uses Finch recovering from his surgery as an excuse for his disappearance when she's actually using Finch as a test subject for June's experimental cure for the walker bite infection. By the time that Padre talks to Finch about revealing that the cure had worked on him, Finch appears to have recovered from his illness and his surgery. (Odessa)
- June mentions that she had treated Hannah for asthma when the girl first came to PADRE. (Blue Jay)
- Madison recalls that one of the parents that she took a kid from had a sick child that the parent thought might've had pneumonia. (Odessa)
- While in King County, Grace reveals to Morgan that she is finally sick and dying from her radiation exposure. Although she was wrong before, after first feeling sick, Grace found a hospital and performed a scan that confirmed it. By the time that Grace tells Morgan, she's already known for a few months. (King County) Grace later reveals that her illness is cancer and that she has at most a year left to live. As a result, the higher dose of radiation that could kill bite victims was able to be used on Grace in an attempt to save her life, but it didn't work. (More Time Than You Know)
- An elderly man seeks the help of Strand's new community for an infected wound. With the help of antibiotics at the community, the man's infection is successfully treated. (Anton)
- Jay suffers from diabetes to the point that he can die without his insulin which a member of his group is able to make for him. After Marty's Group kills everyone else, Jay is left with only a week's supply of insulin which is stolen by the bandits. Although Dwight retrieves Jay's insulin from the Sanctuary for him, Jay succumbs to his diabetes, dies, and reanimates by the time that Dwight returns with the insulin. (Sanctuary)
- Sara tells Strand that she had pneumonia and Alicia had saved her by finding antibiotics for Sara. (Keeping Her Alive)
- Madison gets swamp water in her lungs after nearly drowning, worrying June. (Fighting Like You) After rescuing Madison from the ruins of PADRE, Tracy tells her that she thinks that Madison got an infection in her lungs. However, Tracy was able to treat it with IV antibiotics from PADRE's supplies, having been taught field medicine by her father Troy. (The Road Ahead)
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